منابع مشابه
Metabolite Channelling and Metabolic Complexity
Stoicheiometric analysis of metabolic pathways provides a systematic way of determining which metabolite concentrations are subject to constraints, information that may otherwise be very difficult to recognize in a large branched pathway. The procedure involves representing the pathway structure in the form of a matrix and then carrying out row operations to convert the matrix into 'row echelon...
متن کاملMoiety-conserved cycles and metabolic control analysis: problems in sequestration and metabolic channelling.
This paper considers certain aspects of the analysis of moiety-conserved cycles in terms of metabolic control analysis. Two response coefficients are discussed: the response coefficient with respect to the total number of moles in a cycle (RVT), and the response coefficient with respect to perturbations to the internal state of a pathway (RVS). The relationship between these two different measu...
متن کاملMetabolite Channelling and Metabolic Complexity Substrate channelling in 2-0x0 acid dehydrogenase multienzyme complexes
Heteronuclear NMR spectroscopy and other experiments indicate that the true substrate of the E l component of 2-0x0 acid dehydrogenase complexes is not lipoic acid but the lipoyl domain of the E2 component. E l can recognize the lipoyllysine residue as such, but reductive acylation ensues only if the domain to which the lipoyl group is attached is additionally recognized by virtue of a mosaic o...
متن کاملFailure of channelling to maintain low concentrations of metabolic intermediates.
Computer modelling has been used to investigate the effect of direct transfer of metabolites between consecutive enzymes (channelling) on the free concentrations of the channelled metabolites. When a channelled intermediate cannot participate in any other reactions, any increase in channelling tends to increase its free concentration, albeit very slightly, unless the increase in net flux brough...
متن کاملMetabolic Channelling in Organized Enzyme Systems: Experiments and Models
3 IN VIVO IS NOT THE SAME AS IN VITRO 4 ORGANIZATION LEADS TO CHANNELLING 9 STATIC VERSUS DYNAMIC CHANNELS 10 SOME CONTROVERSIES ABOUT DYNAMIC CHANNELLING 12 MODELLING STRATEGIES FOR STUDYING ENZYMOLOGY IN VIVO 18 CONCLUDING REMARKS 23
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ژورنال
عنوان ژورنال: Molecular and Cellular Biochemistry
سال: 1995
ISSN: 0300-8177,1573-4919
DOI: 10.1007/bf01816949